As scientists push microbial expression systems to produce increasingly complex biologics, downstream purification often becomes the bottleneck; especially when no suitable affinity resin exists for a given target. Shunzyme™, a precision purification technology, aims to change that with streamlined purification of complex biologics. The platform features a standardized affinity capture step and scarless tag removal that leaves the native protein sequence intact. The platform also aims to integrate seamlessly with existing microbial expression workflows and scale into cGMP environments, supporting both development and manufacturing needs.