Native Ion Mobility Mass Spectrometry Advances Extended Characterization and Protein Personality Profiling of Biotherapeutic Proteins

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Native mass spectrometry (nMS) and ion mobility MS (IM-MS) provide direct insight into protein homogeneity, conformation, oligomerization, and PTM-driven structural changes, overcoming limitations of denaturing MS assays. Here, we implement nMS/IM-MS—focusing on collision-induced unfolding (CIU) as an IM-MS–based stability readout—to extend biotherapeutic characterization of monoclonal antibodies (mAbs). CIU reveals discrete, subclass- and stress-dependent stability shifts, supporting applications in high-throughput cell-line screening, developability assessment, formulation optimization, and stability profiling. Download the poster to learn more.
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